Guide to Cannabinoids

Guide to Cannabinoids

You likely know many of the effects of marijuana, but have you ever wondered how one plant can do so many things? From a pleasurable high to effective treatment for a variety of medical conditions, cannabis owes many of its best qualities to cannabinoids. The cannabis plant naturally creates a variety of these compounds, each with specific benefits and potential side effects.

Ongoing research continues to shed light on the potential medicinal benefits of the various compounds. Learning about the different types of cannabinoids and the effects they cause gives you a better understanding of the plant itself and how it could help you with medical conditions.

Simply put, cannabinoids are one of many compounds found in the marijuana plant. These naturally occurring compounds have perhaps the most significance when it comes to marijuana’s effect the body. Cannabinoids claim responsibility for alleviating many ailments, as well as giving you a high. Each cannabinoid is slightly different in both the type and the effects. The concentration of each cannabinoid varies, as well.

Of the 500 natural compounds in the cannabis plant, at least 85 of them fall into the cannabinoid category. Certain cannabinoids stand out for having particular beneficial effects on the body, while most cannabinoids are virtually unknown.

The compounds develop naturally in the cannabis plant, but growers and medical marijuana manufacturers can alter the plant or create synthesized cannabinoid products to produce higher levels of particular cannabinoids. The purpose of this practice is to increase the effects of a particular cannabinoid, making the marijuana strain or synthesized cannabinoid product more appealing to a particular audience.

Your body naturally produces cannabinoids, known as endocannabinoids, which support a variety of body functions, such as your sleep patterns, emotions, movements and appetite. The system within your body is known as the endocannabinoid system. The endocannabinoids play a vital role in keeping you healthy and providing internal stability, or homeostasis.

Essentially, the naturally occurring chemicals in your body facilitate cell communication. Problems with your endocannabinoids can manifest in the form of physical problems and other issues due to the imbalance in your body.

Cannabinoids interact with receptors throughout the body, including the immune system and the central nervous system. The body has two types of receptors: CB1 receptors in the brain and central nervous system and CB2 receptors in the immune system. The cannabinoids in marijuana mimic the natural compounds in your body, binding to receptors inside the body. This binding process is the reason you feel the physical effects of using marijuana, such as feeling relaxed, feeling buzzed or having a slower reaction time.

Different types of cannabinoids tend to bind with receptors in different locations in the body. This is part of the reason certain cannabinoids have particular effects. For example, THC, which is responsible for causing a high, binds well with receptors in the brain. This helps amplify that high feeling.

When you smoke or vape marijuana, the cannabinoids go directly into your lungs quickly and then immediately on to the heart, which gets the cannabinoids to the brain quickly. In the brain, the cannabinoids lock on to the receptors, which initiates the buzzed feeling. The timeframe from first smoking the marijuana to it reaching the brain and beginning the effects takes about 2.5 minutes.

When ingesting an edible containing cannabis, the process takes longer for THC to take full effect. It can take from 30 minutes to 2 hours to feel the effects. However, once the marijuana kicks in, the effects are much more intense than other forms of using marijuana.

The different cannabinoids in cannabis affect the receptors differently, depending on the specific cannabinoid and the location in the body. The foundation of medicinal marijuana is targeting the type of cannabinoids to specific receptors in the body for maximum effect on a particular problem. Marijuana manufactured as medicine includes a larger amount of specific cannabinoids to treat particular symptoms. Understanding the effects of cannabinoids helps with the specific treatment course when you use marijuana for medicinal purposes.

While the specific benefits vary from one cannabinoid to the next, many common benefits are found in many types of these compounds. These benefits are often the reason people seek marijuana for medical reasons. Some of the primary benefits of cannabinoids include:

Cannabinoids fall into two different categories: psychoactive and non-psychoactive. This classification influences the way a particular compound affects your body. Psychoactive cannabinoids give you the high feeling often associated with using marijuana. THC is the primary psychoactive cannabinoid in marijuana. Cannabinol, or CBN, is another psychoactive compound found in cannabis.

Non-psychoactive cannabinoids don’t cause the high feeling. They do have other effects on the body, sometimes very significant effects, but they aren’t responsible for giving you the buzzed feeling. Cannabidiol, or CBD, is one of the most prominent non-psychoactive cannabinoids in marijuana. People who use marijuana for medicinal purposes benefit from the non-psychoactive cannabinoids when they don’t want the buzz.

While there are more than 85 different types of cannabinoids, only a handful get the spotlight when people talk about the effects of marijuana. Those primary cannabinoids often receive the most attention in research regarding cannabis, which means we know more about how they work and their effects. That doesn’t mean these are the only beneficial cannabinoids, however.

The benefits and side effects of cannabinoids vary significantly. When doing your research, keep in mind that individuals respond differently to various cannabinoids. With the use of medical marijuana, the concentrations of various cannabinoids also influence the effects in your body. The side effects of a particular cannabinoid might be more noticeable with higher concentrations, for example.

Another consideration is your perspective. Some effects of a particular cannabinoid are a positive for certain people. Other people don’t want that effect, so they see it as a negative. For example, a cannabinoid that creates that high feeling is a positive for someone who wants to feel a high, such as a recreational marijuana user. Someone who wants to reap the medicinal benefits of marijuana without feeling high sees it as a negative.

Drowsiness and appetite stimulation are two other examples. Someone who has trouble sleeping appreciates the drowsy effect, while someone who wants to use marijuana but stay alert sees it as a negative. A person who needs to eat more for health reasons benefits from cannabinoids that stimulate the appetite, while someone who doesn’t want to eat more won’t benefit from that effect.

Understanding the different types of cannabinoids helps you maximize the positive effects while minimizing the unwanted ones.

If you’ve heard of any cannabinoid, it is likely tetrahydrocannabinol (THC). It is the most widely known of the cannabinoids and is typically found in high concentrations in most strains of the plant. THC causes the buzzed high you feel after using marijuana due to its psychoactive properties. It is the main psychoactive compound found in the plant, and marijuana is often cultivated to have higher THC levels.

The side effects of THC often come with a dose that is too high, so lowering the dose can help minimize the effects. Side effects often vary from one person to the next.

Another common and influential cannabinoid is cannabidiol (CBD). This non-psychoactive compound calms your high, helping to balance the effects of THC. CBD is known for many medicinal benefits and is legal in more states than THC. Some medical marijuana users like the option to treat symptoms with minimized feelings of euphoria or lethargy in strains grown to offer higher CBD levels.

While CBD tends to have fewer side effects than THC, some users do experience some side effects, including:

The drowsiness can be a positive or negative effect depending on your goals. If you want to sleep better, the drowsiness falls under the benefits column. If you want to remain alert, drowsiness becomes a negative effect of CBD.

Cannabinol (CBN) forms through an oxidation process when THC is exposed to air. This means bud left out in the air longer than normal ends up with a higher concentration of CBN. Many users keep their marijuana in tightly sealed containers to keep air away from it, since the exposure decreases THC levels. Like THC, CBN is a psychoactive, but it performs at a much lower level than THC.  CBN also differs from THC in its tendency to bind to receptors throughout the body rather than receptors in the brain.

CBN offers an advantage over THC in another way. While it is a psychoactive cannabinoid, CBN causes little to no psychoactive effects. THC content can be as high as 30 percent, but CBN typically hits 1 percent or less. While this decreased psychoactive effect dose not appeal to recreational marijuana users who look for the high, it is an advantage to those who want the medicinal benefits without the high.

The sedative effect of CBN makes it a popular cannabinoid for people who suffer from insomnia or sleep issues. For some people, the drowsiness created by CBN is a drawback, but many people want the sleep-inducing effects of CBN. The cannabinoid offers effects similar to pharmaceutical sedatives in smaller doses. Just 5 mg of CBN offers the same sedative effects as 10 mg of the mild pharmaceutical sedative called diazepam.

The non-psychoactive compound cannabigerol (CBG) serves as a foundation for THC and CBD. Because it forms early in the growing cycle, CBG typically isn’t found in large quantities as the plant matures. CBG receives less attention in studies on cannabinoids, but it offers the potential for significant medicinal uses. Strains of marijuana with higher CBG levels tend to minimize the negative effects of THC in many users.

This non-psychoactive cannabinoid is less known than some other types, but it still offers some impressive benefits. Even though it isn’t widely known, CBC ranks as the second most available cannabinoid in marijuana – even higher than the more popular CBD.

It’s easy to see the benefits of cannabinoids when you start breaking down the different types. Cannabinoids have individual strengths that are great on their own, but the combined effect of cannabinoids seems to boost the positive effects of the individual compounds. Research shows that this entourage effect can drastically change a person’s reaction to marijuana.

While all marijuana comes from the cannabis plant, the specifics of that plant vary widely. There are thousands of different strains of marijuana. The chemical profile of each strain varies from the next. This means the cannabinoids and other compounds in the plant, such as terpenes, ketones, alcohols and fatty acids, come in different concentrations depending on the strain. For this reason, you might have drastically different experiences when you use two different strains of marijuana.

The concentration of those chemicals can also change the intensity of the effects of a particular cannabinoid. Research often shows that putting particular cannabinoids together can change the effectiveness or overall effects compared to using only one cannabinoid.

Having an understanding of individual cannabinoids helps you better understand how marijuana affects your body and potentially offers medicinal effects for specific conditions. If you’re ready to take advantage of the positive benefits of marijuana, get started by searching for a medical marijuana doctor or a local dispensary.

Posted by Jason Draizin on 01/17/2017 in Medical Marijuana

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